PDB entry 3tgg
View 3tgg on RCSB PDB site
Description: A novel series of potent and selective PDE5 inhibitor2
Class: hydrolase/hydrolase inhibitor
Keywords: phosphodiesterase, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2011-08-17, released
2012-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-01-25, with a file datestamp of
2012-01-20.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.188
AEROSPACI score: 0.5
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
Species: Homo sapiens [TaxId:9606]
Gene: PDE5A, PDE5
Database cross-references and differences (RAF-indexed):
- Uniprot O76074 (Start-325)
- engineered mutation (124)
- expression tag (127)
- engineered mutation (129-131)
- expression tag (133)
- engineered mutation (134-135)
- engineered mutation (140-141)
- expression tag (143)
- engineered mutation (144-145)
- engineered mutation (147)
- engineered mutation (147)
- engineered mutation (218)
Domains in SCOPe 2.08: d3tgga_ - Heterogens: ZN, MG, 0H3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3tggA (A:)
eeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeyktt
lkiikqailatdlalyikrrgeffelirknqfnledphekelflamlmtacdlsaitkpw
piqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyeal
thvsedcfplldgcrknrqkwqalae
Sequence, based on observed residues (ATOM records): (download)
>3tggA (A:)
etrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevl
crwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdl
dhpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphekelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalae