PDB entry 3t19

View 3t19 on RCSB PDB site
Description: Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05
Class: transferase/transferase inhibitor
Keywords: HIV-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, HIV-1, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-07-21, released 2011-10-26
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-02-01, with a file datestamp of 2012-01-27.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.202
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: reverse transcriptase
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Gene: gag-pol, HIV-1 pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.05: d3t19a1, d3t19a2
  • Chain 'B':
    Compound: reverse transcriptase
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Gene: gag-pol, HIV-1 pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3t19b_
  • Heterogens: 5MA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3t19A (A:)
mnspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyn
tpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfs
vpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpd
iviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpd
kwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplte
eaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarm
rgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefv
ntpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqkt
elqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp
ahkgiggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >3t19A (A:)
spispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
vfaiktkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiy
lalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgig
gneqvdklvsagir

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3t19B (B:)
mnspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyn
tpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfs
vpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpd
iviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpd
kwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplte
eaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarm
rgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefv
ntpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqkt
elqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp
ahkgiggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >3t19B (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikt
kwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkyta
ftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyv
gsdleigqhrtkieelrqhllrwgltgyelhpdkwtvqpivlpekdswtvndiqklvgkl
nwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskd
liaeiqkqgqgqwtyqiyqepfknlktgkyarhtndvkqlteavqkittesiviwgktpk
fklpiqketwetwwteywqatwipewefvntpplvklwyq