PDB entry 3srv
View 3srv on RCSB PDB site
Description: Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor
Class: transferase/transferase inhibitor
Keywords: SK363, SYK, non-receptor tyrosine kinase, spleen tyrosine kinase, TRANSFERASE, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-07-07, released
2011-09-21
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-10-12, with a file datestamp of
2011-10-07.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.188
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase SYK
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d3srva_ - Chain 'B':
Compound: Tyrosine-protein kinase SYK
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d3srvb_ - Heterogens: S19, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3srvA (A:)
gpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdell
aeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqv
smgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkw
yapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcp
remydlmnlcwtydvenrpgfaavelrlrnyyydvvn
Sequence, based on observed residues (ATOM records): (download)
>3srvA (A:)
yldrklltledkelgnfgtvkkgyyqmkkvvktvavkilkalkdellaeanvmqqldnpy
ivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfv
hrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyykfss
ksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwty
dvenrpgfaavelrlrnyyydvv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3srvB (B:)
gpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdell
aeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqv
smgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkw
yapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcp
remydlmnlcwtydvenrpgfaavelrlrnyyydvvn
Sequence, based on observed residues (ATOM records): (download)
>3srvB (B:)
yldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqldn
pyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesn
fvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyykf
ssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcw
tydvenrpgfaavelrlrnyyyd