PDB entry 3sru
View 3sru on RCSB PDB site
Description: S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: dihydrofolate reductase, DHFR, drug design, enzyme inhibitors, folate, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on
2011-07-07, released
2011-08-31
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-10-19, with a file datestamp of
2011-10-14.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.183
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'X':
Compound: dihydrofolate reductase
Species: Staphylococcus aureus [TaxId:1280]
Gene: folA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3srux_ - Heterogens: NAP, Q26, HOH
PDB Chain Sequences:
- Chain 'X':
Sequence, based on SEQRES records: (download)
>3sruX (X:)
mtlsilvahdlqrvigfenqlpwhlpndlkhvkklstghtlvmgrktfesigkplpnrrn
vvltsdtsfnvegvdvihsiediyqlpghvfifggqtlfeemidkvddmyitviegkfrg
dtffppytfedwevassvegkldekntiphtflhlirkklehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3sruX (X:)
tlsilvahdlqrvigfenqlpwhlpndlkhvkklstghtlvmgrktfesigkplpnrrnv
vltsdtsfnvegvdvihsiediyqlpghvfifggqtlfeemidkvddmyitviegkfrgd
tffppytfedwevassvegkldekntiphtflhlirk