PDB entry 3so3

View 3so3 on RCSB PDB site
Description: Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.
Class: hydrolase
Keywords: antibody-protein, protein-protein, protease inhibitor, disease mutation, glycoprotein, hydrolase, membrane, serine protease, signal-anchor, transmembrane
Deposited on 2011-06-29, released 2012-06-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-06-20, with a file datestamp of 2012-06-15.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.162
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Suppressor of tumorigenicity 14 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS14, SNC19, ST14, TADG15
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Y6 (0-240)
      • engineered mutation (116)
    Domains in SCOPe 2.07: d3so3a_
  • Chain 'B':
    Compound: A11 FAB light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3SO3 (0-End)
    Domains in SCOPe 2.07: d3so3b1, d3so3b2
  • Chain 'C':
    Compound: A11 FAB heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3SO3 (0-End)
  • Heterogens: GOL, SUC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3so3A (A:)
    vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
    flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
    ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
    sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
    v
    

    Sequence, based on observed residues (ATOM records): (download)
    >3so3A (A:)
    vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
    flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
    ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
    sggvdscqgdsggplssvedgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentgv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3so3B (B:)
    eivltqspgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygastratgip
    arfsgsgsgtdftltinslepedfavyycqqrsnwppgytfgqgtkveitrtvaapsvfi
    fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
    tltlskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >3so3B (B:)
    eivltqspgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygastratgip
    arfsgsgsgtdftltinslepedfavyycqqrsnwppgytfgqgtkveitrtvaapsvfi
    fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
    tltlskadyekhkvyacevthqglsspvtksfnrge
    

  • Chain 'C':
    No sequence available.