PDB entry 3se6

View 3se6 on RCSB PDB site
Description: Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2
Class: hydrolase
Keywords: Thermolysin-like catalytic domain, Aminopeptidase, Zinc binding, Glycosylation, Endoplasmic Reticulum, HYDROLASE
Deposited on 2011-06-10, released 2011-12-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.08 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • see remark 999 (391)
      • expression tag (960)
    Domains in SCOPe 2.08: d3se6a1, d3se6a2, d3se6a3, d3se6a4, d3se6a5
  • Chain 'B':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • see remark 999 (391)
      • expression tag (960)
    Domains in SCOPe 2.08: d3se6b1, d3se6b2, d3se6b3, d3se6b4, d3se6b5
  • Heterogens: ZN, LYS, NAG, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3se6A (A:)
mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3se6A (A:)
pvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhsk
dleitnatlqseeymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgf
egfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnm
pkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqt
hyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpkts
sasdklwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddy
flnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqk
giiqylkkfsyrnaknddlwsslsnslgenaevkemmttwtlqkgipllvvkqdgcslrl
qqerflqgqerylwhipltystsssnvihrhilksktdtldlpektswvkfnvdsngyyi
vhyeghgwdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldmtyylqhets
spalleglsylesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkgsvwdrmlrs
allklacdlnhapciqkaaelfsqwmessgklniptdvlkivysvgaqttagwnylleqy
elsmssaeqnkilyalstskhqekllklielgmegkviktqnlaallhaiarrpkgqqla
wdfvrenwthllkkfdlgsydirmiisgttahfsskdklqevklffesleaqgshldifq
tvletitknikwleknlptlrtwlmvntr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3se6B (B:)
mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3se6B (B:)
vatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskd
leitnatlqsepgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfyk
styrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvkt
ielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyalq
aslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasdk
lwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnvc
fevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiqy
lkkfsyrnaknddlwsslsnsaevkemmttwtlqkgipllvvkqdgcslrlqqerflqgv
rylwhipltystsssnvihrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdq
litqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldmtyylqhetsspalleglsy
lesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdln
hapciqkaaelfsqwmessgklniptdvlkivysvgaqttagwnylleqyelsmssaeqn
kilyalstskhqekllklielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwth
llkkfdlgsydirmiisgttahfsskdklqevklffesleaqgshldifqtvletitkni
kwleknlptlrtwlmvntr