PDB entry 3s6n

View 3s6n on RCSB PDB site
Description: Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1/D2/F/E/G from Human
Class: splicing
Keywords: SMN complex, SMN-Gemin2 complex, U-rich snRNA, Sm fold, Sm core, snRNPs, snRNP Biogenesis, pre-mRNA SPLICING, SPLICEOSOME, HETEROMERIC HEPTAMERIC RING, protein complex, Splicing, mRNA, helix protein, Survival of Motor Neuron, Splicing factor, RNA binding
Deposited on 2011-05-25, released 2011-08-17
Made obsolete by 5xjl on 2018-05-02

The last revision prior to the SCOPe 2.06 freeze date was dated 2011-08-17, with a file datestamp of 2011-08-12.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.258
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

• Chain '2':
  Compound: Survival of motor neuron protein-interacting protein 1
  Species: Homo sapiens [TaxId:9606]
  Gene: SIP1, GEMIN2
  Database cross-references and differences (RAF-indexed):
  • Uniprot O14893
• Chain 'A':
  Compound: Small nuclear ribonucleoprotein Sm D1
  Species: Homo sapiens [TaxId:9606]
  Gene: SNRPD1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62314 (0-End)
  Domains in SCOPe 2.06: d3s6na_
• Chain 'B':
  Compound: Small nuclear ribonucleoprotein Sm D2
  Species: Homo sapiens [TaxId:9606]
  Gene: SNRPD2, SNRPD1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62316
  Domains in SCOPe 2.06: d3s6nb_
• Chain 'E':
  Compound: Small nuclear ribonucleoprotein E
  Species: Homo sapiens [TaxId:9606]
  Gene: SNRPE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62304
• Chain 'F':
  Compound: Small nuclear ribonucleoprotein F
  Species: Homo sapiens [TaxId:9606]
  Gene: SNRPF, PBSCF
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62306
  Domains in SCOPe 2.06: d3s6nf_
• Chain 'G':
  Compound: Small nuclear ribonucleoprotein G
  Species: Homo sapiens [TaxId:9606]
  Gene: SNRPG, PBSCG
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62308
  Domains in SCOPe 2.06: d3s6ng_
• Chain 'M':
  Compound: Survival motor neuron protein
  Species: Homo sapiens [TaxId:9606]
  Gene: SMN1, SMN, SMNT, SMN2, SMNC
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q16637
• Heterogens: HOH

PDB Chain Sequences:

• Chain '2':
  No sequence available.
  
  
• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3s6nA (A:)
  mklvrflmklshetvtielkngtqvhgtitgvdvsmnthlkavkmtlknrepvqletlsi
  rgnniryfilpdslpldtllvdvepkvkskkreavagrgrgrgrgrgrgrgrgrggprr
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3s6nA (A:)
  mklvrflmklshetvtielkngtqvhgtitgvdvsmnthlkavkmtlknrepvqletlsi
  rgnniryfilpdslpldtllv
  

  
  
• Chain 'B':
  Sequence, based on SEQRES records: (download)
  

  >3s6nB (B:)
  msllnkpksemtpeelqkreeeefntgplsvltqsvknntqvlincrnnkkllgrvkafd
  rhcnmvlenvkemwtevpksgkgkkkskpvnkdryiskmflrgdsvivvlrnpliagk
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3s6nB (B:)
  efntgplsvltqsvknntqvlincrnnkkllgrvkafdrhcnmvlenvkemwtevnkdry
  iskmflrgdsvivvlrnplia
  

  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  Sequence, based on SEQRES records: (download)
  

  >3s6nF (F:)
  mslplnpkpflngltgkpvmvklkwgmeykgylvsvdgymnmqlanteeyidgalsghlg
  evlircnnvlyirgveeeeedgemre
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3s6nF (F:)
  lplnpkpflngltgkpvmvklkwgmeykgylvsvdgymnmqlanteeyidgalsghlgev
  lircnnvlyirgve
  

  
  
• Chain 'G':
  Sequence, based on SEQRES records: (download)
  

  >3s6nG (G:)
  mskahppelkkfmdkklslklnggrhvqgilrgfdpfmnlvidecvematsgqqnnigmv
  virgnsiimlealerv
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3s6nG (G:)
  dkklslklnggrhvqgilrgfdpfmnlvidecvematsnigmvvirgnsiimlea
  

  
  
• Chain 'M':
  No sequence available.