PDB entry 3rvb

View 3rvb on RCSB PDB site
Description: The structure of HCV NS3 helicase (Heli-80) bound with inhibitor ITMN-3479
Class: hydrolase/hydrolase inhibitor
Keywords: Helicase, ATP hydrolysis, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-05-06, released 2014-09-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-24, with a file datestamp of 2014-09-19.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.227
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA helicase
    Species: Hepatitis C virus [TaxId:11103]
    Gene: NS3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663
      • conflict (51)
      • conflict (95)
      • conflict (113)
      • conflict (118)
      • conflict (120)
      • conflict (154)
      • conflict (213)
      • conflict (238)
      • conflict (241)
      • conflict (258)
      • conflict (302)
      • conflict (439)
      • conflict (441)
      • conflict (460)
      • conflict (470)
      • conflict (473)
    Domains in SCOPe 2.08: d3rvba1, d3rvba2
  • Heterogens: I79, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3rvbA (A:)
mgrgshhhhhhgmastrgvakavdfvpvesmettmrspvftdnssppavpqtfqvahlha
ptgsgkstkvpaayaaqgykvlvlnpsvaatlgfgvymskahgidpnirtgvraittggp
itystygkfladggcsggaydiiicdechstdstsilgigtvldqaetagarlvvlatat
ppgsvtvphpnieevalsntgeipfygkaipievirggrhlifchskkkcdelaaklsal
glnavayyrgldvsviptsgdvvvvatdalmtgytgdfdsvidcntcvtqtvdfsldptf
tidtttvpqdavsrsqrrgrtgrgrrgiyrfvtpgerpsgmfdssvlcecydagcawyel
tpaetsvrlraylntpglpvcqdhlefwesvftglthidahflsqtkqagdnfpylvayq
atvcaraqapppswdqmwksltrlkptlhgptpllyrlgalqnevtlthpvtkfimacms
adlevvtaaarea

    Sequence, based on observed residues (ATOM records): (download) 
    >3rvbA (A:)
dnssppavpqtfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfgvymska
hgidpnirtgvraittggpitystygkfladggcsaydiiicdechstdstsilgigtvl
dqaetagarlvvlatatppgsvtvphpnieevalsntgeipfygkaipievirggrhlif
chskkkcdelaaklsalglnavayyrgldvsviptsgdvvvvatdalmtgytgdfdsvid
cntcvtqtvdfsldptftidtttvpqdavsrsqrrgrtgrgrrgiyrfvtpgerpsgmfd
ssvlcecydagcawyeltpaetsvrlraylntpglpvcqdhlefwesvftglthidahfl
sqtkqagdnfpylvayqatvcaraqapppswdqmwksltrlkptlhgptpllyrlgalqn
evtlthpvtkfimacmsadlevv