PDB entry 3rkz

View 3rkz on RCSB PDB site
Description: Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model.
Class: chaperone/chaperone inhibitor
Keywords: Chaperone, ATP binding domain, ATP-binding, Nucleotide-binding, Phosphoprotein, Stress response, CHAPERONE-CHAPERONE INHIBITOR complex
Deposited on 2011-04-18, released 2011-07-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-08-03, with a file datestamp of 2011-07-29.
Experiment type: XRAY
Resolution: 1.57 Å
R-factor: 0.167
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock protein HSP 90-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90A, HSP90AA1, HSPC1, HSPCA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3rkza_
  • Heterogens: 06T, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3rkzA (A:)
qpmeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskl
dsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadism
igqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhl
kedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >3rkzA (A:)
vetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgkel
hinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfgv
gfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqte
yleerrikeivkkhsqfigypitlfvek