PDB entry 3qxt

View 3qxt on RCSB PDB site
Description: Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody in Complex with Methotrexate
Class: immune system
Keywords: Camelid Single Domain Antibody, Heavy Chain Only, VHH, Antibody, Anti-Hapten Antibody, CDR, Hapten Binding, Small Molecule Sensing, Ligand Binding, Low Molecular Weight Compound, Methotrexate, IMMUNE SYSTEM
Deposited on 2011-03-02, released 2011-07-06
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-09-11, with a file datestamp of 2013-09-06.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.176
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Anti-Methotrexate CDR1-3 Graft VHH
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QXT (Start-125)
    Domains in SCOPe 2.04: d3qxta_
  • Chain 'B':
    Compound: Anti-Methotrexate CDR1-3 Graft VHH
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QXT (Start-125)
    Domains in SCOPe 2.04: d3qxtb_
  • Heterogens: MTX, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qxtA (A:)
gsqvqlvesggglvqaggslrlscaasrrssrswamawfrqapgkerefvakisgdgrlt
tygdsvkgrftisrdkgkntvylqmdslkpedtavyycaaddnyvtaswrsgpdywgqgt
qvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >3qxtA (A:)
qvqlvesggglvqaggslrlscaasrrssrswamawfrqapgkerefvakisgdgrltty
gdsvkgrftisrdkgkntvylqmdslkpedtavyycaaddnyvtaswrsgpdywgqgtqv
tvss

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qxtB (B:)
gsqvqlvesggglvqaggslrlscaasrrssrswamawfrqapgkerefvakisgdgrlt
tygdsvkgrftisrdkgkntvylqmdslkpedtavyycaaddnyvtaswrsgpdywgqgt
qvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >3qxtB (B:)
qvqlvesggglvqaggslrlscaasrrssrswamawfrqapgkerefvakisgdgrltty
gdsvkgrftisrdkgkntvylqmdslkpedtavyycaaddnyvtaswrsgpdywgqgtqv
tvss