PDB entry 3qlh

View 3qlh on RCSB PDB site
Description: HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket
Class: transferase,hydrolase/inhibitor
Keywords: RNase H Inhibitor, structure-based drug design, tropolone derivatives, divalent cation chelator, Non-nucleoside RT Inhibitor, TRANSFERASE,HYDROLASE-INHIBITOR complex
Deposited on 2011-02-02, released 2011-12-21
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-06-17, with a file datestamp of 2015-06-12.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus type 1 [TaxId:11678]
    Gene: Gag-Pol, pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (1-554)
      • expression tag (0)
      • engineered mutation (172-173)
      • engineered mutation (280)
    Domains in SCOPe 2.06: d3qlha1, d3qlha2, d3qlha3
  • Chain 'B':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus type 1 [TaxId:11678]
    Gene: Gag-Pol, pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (0-422)
      • engineered mutation (274)
    Domains in SCOPe 2.06: d3qlhb_
  • Heterogens: MNK, T27, MN, DMS, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3qlhA (A:)
vpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
vfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvp
ldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdiv
iyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkw
tvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteea
elelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrg
ahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvnt
pplvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktel
qaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpah
kgiggneqvdklvsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qlhB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyq

    Sequence, based on observed residues (ATOM records): (download) 
    >3qlhB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfweviphpaglkkkksvtvldvgdayfsvpldedfrkyt
aftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddly
vgsdleigqhrtkieelrqhllrwgflwmgyelhpdkwtvqpivlpekdswtvndiqklv
gklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydp
skdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiv
iwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq