PDB entry 3qgw

View 3qgw on RCSB PDB site
Description: Crystal Structure of ITK kinase bound to an inhibitor
Class: transferase/transferase inhibitor
Keywords: Protein Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-01-25, released 2011-06-22
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-06-22, with a file datestamp of 2011-06-17.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.245
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ITK/TSK
    Species: Homo sapiens [TaxId:9606]
    Gene: ITK, EMT, LYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08881
      • conflict (59)
      • conflict (62)
      • conflict (66)
    Domains in SCOPe 2.03: d3qgwa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase ITK/TSK
    Species: Homo sapiens [TaxId:9606]
    Gene: ITK, EMT, LYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08881
      • conflict (59)
      • conflict (62)
      • conflict (66)
    Domains in SCOPe 2.03: d3qgwb_
  • Heterogens: PQC, L7A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3qgwA (A:)
    mgsshhhhhhssglvprgslhmvidpseltfvqeigsgqfglvhlgywlnkdkvaiktik
    egsmseddfieeaevmmklshpklvqlygvcleqapiclvfefmehgclsdylrtqrglf
    aaetllgmcldvcegmayleeacvihrdlaarnclvgenqvikvsdfgmtrfvlddqyts
    stgtkfpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipyenrsnsevvedistg
    frlykprlasthvyqimnhcwkerpedrpafsrllrqlaeiaesgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3qgwA (A:)
    idpseltfvqeigsgqfglvhlgywlnkdkvaiktikegsmseddfieeaevmmklshpk
    lvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeac
    vihrdlaarnclvgenqvikvsdfgfpvkwaspevfsfsryssksdvwsfgvlmwevfse
    gkipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlae
    iaes
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3qgwB (B:)
    mgsshhhhhhssglvprgslhmvidpseltfvqeigsgqfglvhlgywlnkdkvaiktik
    egsmseddfieeaevmmklshpklvqlygvcleqapiclvfefmehgclsdylrtqrglf
    aaetllgmcldvcegmayleeacvihrdlaarnclvgenqvikvsdfgmtrfvlddqyts
    stgtkfpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipyenrsnsevvedistg
    frlykprlasthvyqimnhcwkerpedrpafsrllrqlaeiaesgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3qgwB (B:)
    idpseltfvqeigsgqfglvhlgywlnkdkvaiktikegsmseddfieeaevmmklshpk
    lvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeac
    vihrdlaarnclvgenqvikvsdfpvkwaspevfsfsryssksdvwsfgvlmwevfsegk
    ipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeia