SCOPe 2.05: Structural Classification of Proteins

PDB entry 3qfc

View 3qfc on RCSB PDB site
Description: Crystal Structure of Human NADPH-Cytochrome P450 (V492E mutant)
Class: oxidoreductase
Keywords: human CYPOR, cytochrome P450 reductase, flavoprotein, FAD, FMN, NADPH, OXIDOREDUCTASE
Deposited on 2011-01-21, released 2011-08-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-08-31, with a file datestamp of 2011-08-26.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.232
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: NADPH--cytochrome P450 reductase
Species: Homo sapiens [TaxId:9606]
Gene: POR, CYPOR
Database cross-references and differences (RAF-indexed):
- Uniprot P16435 (Start-617)
  - see remark 999 (165)
  - engineered mutation (429)
  - see remark 999 (440)
Domains in SCOPe 2.05: d3qfca1, d3qfca2, d3qfca3
Chain 'B':
Compound: NADPH--cytochrome P450 reductase
Species: Homo sapiens [TaxId:9606]
Gene: POR, CYPOR
Database cross-references and differences (RAF-indexed):
- Uniprot P16435 (Start-617)
  - see remark 999 (165)
  - engineered mutation (429)
  - see remark 999 (440)
Domains in SCOPe 2.05: d3qfcb1, d3qfcb2, d3qfcb3
Heterogens: FAD, FMN, NAP, CA, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3qfcA (A:)
gshmvressfvekmkktgrniivfygsqtgtaeefanrlskdahrygmrgmsadpeeydl
adlsslpeidnalvvfcmatygegdptdnaqdfydwlqetdvdlsgvkfavfglgnktye
hfnamgkyvdkrleqlgaqrifelglgdddgnleedfitwreqfwlavcehfgveatgee
ssirqyelvvhtdidaakvymgemgrlksyenqkppfdaknpflaavttnrklnqgterh
lmhleldisdskiryesgdhvavypandsalvnqlgkilgadldvvmslnnldeesnkkh
pfpcptsyrtaltyylditnpprtnvlyelaqyasepseqellrkmasssgegkelylsw
vvearrhilailqdcpslrppidhlcellprlqaryysiassskvhpnsvhicavvveye
tkagrinkgeatnwlrakepvgenggralvpmfvrksqfrlpfkattpvimvgpgtgvap
figfiqerawlrqqgkevgetllyygcrrsdedylyreelaqfhrdgaltqlnvafsreq
shkvyvqhllkqdrehlwklieggahiyvcgdarnmardvqntfydivaelgamehaqav
dyikklmtkgrysldvws

Sequence, based on observed residues (ATOM records): (download)

>3qfcA (A:)
essfvekmkktgrniivfygsqtgtaeefanrlskdahrygmrgmsadpeeydladlssl
peidnalvvfcmatygegdptdnaqdfydwlqetdvdlsgvkfavfglgnktyehfnamg
kyvdkrleqlgaqrifelglgdddgnleedfitwreqfwlavcehfgveatgeessirqy
elvvhtdidaakvymgemgrlksyenqkppfdaknpflaavttnrklnqgterhlmhlel
disdskiryesgdhvavypandsalvnqlgkilgadldvvmslnnldeesnkkhpfpcpt
syrtaltyylditnpprtnvlyelaqyasepseqellrkmasssgegkelylswvvearr
hilailqdcpslrppidhlcellprlqaryysiassskvhpnsvhicavvveyetkagri
nkgeatnwlrakepvralvpmfvrksqfrlpfkattpvimvgpgtgvapfigfiqerawl
rqqgkevgetllyygcrrsdedylyreelaqfhrdgaltqlnvafsreqshkvyvqhllk
qdrehlwklieggahiyvcgdarnmardvqntfydivaelgamehaqavdyikklmtkgr
ysldvws

Chain 'B':
Sequence, based on SEQRES records: (download)

>3qfcB (B:)
gshmvressfvekmkktgrniivfygsqtgtaeefanrlskdahrygmrgmsadpeeydl
adlsslpeidnalvvfcmatygegdptdnaqdfydwlqetdvdlsgvkfavfglgnktye
hfnamgkyvdkrleqlgaqrifelglgdddgnleedfitwreqfwlavcehfgveatgee
ssirqyelvvhtdidaakvymgemgrlksyenqkppfdaknpflaavttnrklnqgterh
lmhleldisdskiryesgdhvavypandsalvnqlgkilgadldvvmslnnldeesnkkh
pfpcptsyrtaltyylditnpprtnvlyelaqyasepseqellrkmasssgegkelylsw
vvearrhilailqdcpslrppidhlcellprlqaryysiassskvhpnsvhicavvveye
tkagrinkgeatnwlrakepvgenggralvpmfvrksqfrlpfkattpvimvgpgtgvap
figfiqerawlrqqgkevgetllyygcrrsdedylyreelaqfhrdgaltqlnvafsreq
shkvyvqhllkqdrehlwklieggahiyvcgdarnmardvqntfydivaelgamehaqav
dyikklmtkgrysldvws

Sequence, based on observed residues (ATOM records): (download)

>3qfcB (B:)
ssfvekmkktgrniivfygsqtgtaeefanrlskdahrygmrgmsadpeeydladlsslp
eidnalvvfcmatygegdptdnaqdfydwlqetdvdlsgvkfavfglgnktyehfnamgk
yvdkrleqlgaqrifelglgdddgnleedfitwreqfwlavcehfgveatgeirqyelvv
htdidaakvymgemgrlksyenqkppfdaknpflaavttnrklnqgterhlmhleldisd
skiryesgdhvavypandsalvnqlgkilgadldvvmslnnldeesnkkhpfpcptsyrt
altyylditnpprtnvlyelaqyasepseqellrkmasssgegkelylswvvearrhila
ilqdcpslrppidhlcellprlqaryysiassskvhpnsvhicavvveykgeatnwlrak
epvralvpmfvrksqfrlpfkattpvimvgpgtgvapfigfiqerawlrqqgkevgetll
yygcrrsdedylyreelaqfhrdgaltqlnvafsreqshkvyvqhllkqdrehlwklieg
gahiyvcgdarnmardvqntfydivaelgamehaqavdyikklmtkgrysldvws