PDB entry 3qeq

View 3qeq on RCSB PDB site
Description: The complex between TCR DMF4 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide
Class: immune system
Keywords: MART-1 peptide, nonapeptide, MHC class I, HLA-A2, TCR DMF5, TCR DMF4, cross-reactivity, cancer, melanoma, IMMUNE SYSTEM
Deposited on 2011-01-20, released 2011-07-06
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-09-07, with a file datestamp of 2011-09-02.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: 0.218
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3qeqa1, d3qeqa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.05: d3qeqb_
  • Chain 'C':
    Compound: MART-1(27-35) peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3QEQ (0-8)
  • Chain 'D':
    Compound: DMF4 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QEQ (0-193)
    Domains in SCOPe 2.05: d3qeqd1, d3qeqd2
  • Chain 'E':
    Compound: DMF4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QEQ (0-242)
    Domains in SCOPe 2.05: d3qeqe1, d3qeqe2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3qeqA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3qeqB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3qeqD (D:)
qlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngrlt
aqfgitrkdsflnisasipsdvgiyfcaggtgnqfyfgtgtsltvipniqnpdpavyqlr
dskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfac
anafnnsiipedtf

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3qeqE (E:)
dagitqsprhkvtetgtpvtlrchqtenhrymywyrqdpghglrlihysygvkdtdkgev
sdgysvsrsktedflltlesatssqtsvyfcaisevgvgqpqhfgdgtrlsiledlnkvf
ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
alndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
rad