PDB entry 3qb4

View 3qb4 on RCSB PDB site
Description: Crystal structure of a TGF-beta ligand-receptor complex
Class: cytokine/transferase receptor
Keywords: CYSTINE-KNOT, Ligand-receptor complex, Protein, Membrane/Extracellular, CYTOKINE-TRANSFERASE RECEPTOR complex
Deposited on 2011-01-12, released 2012-03-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-10-07, with a file datestamp of 2015-10-02.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: CDMP1, GDF5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43026 (Start-116)
      • engineered mutation (53)
    Domains in SCOPe 2.06: d3qb4a_
  • Chain 'B':
    Compound: Bone morphogenetic protein receptor type-1A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVRLK3, ALK3, BMPR1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3qb4b_
  • Chain 'C':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: CDMP1, GDF5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43026 (Start-116)
      • engineered mutation (53)
    Domains in SCOPe 2.06: d3qb4c_
  • Chain 'D':
    Compound: Bone morphogenetic protein receptor type-1A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVRLK3, ALK3, BMPR1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3qb4d_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3qb4A (A:)
    mkrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashlept
    nhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr
    

    Sequence, based on observed residues (ATOM records): (download)
    >3qb4A (A:)
    karcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashleptnhaviqtlmnsm
    dpestpptccvptrlspisilfidsannvvykqyedmvvescgcr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3qb4B (B:)
    gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntci
    tnghcfaiieeddqgettlasgcmkyegsdfqckdspkaqlrrtieccrtnlcnqylqpt
    lppvvigpffdgsir
    

    Sequence, based on observed residues (ATOM records): (download)
    >3qb4B (B:)
    dtlpflkcycsghcpddainntcitnghcfaiieeddqgettlasgcmkyegsdfqckds
    pkaqlrrtieccrtnlcnqylqptlppv
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3qb4C (C:)
    mkrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashlept
    nhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr
    

    Sequence, based on observed residues (ATOM records): (download)
    >3qb4C (C:)
    lkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashleptnhaviqtlmns
    mdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3qb4D (D:)
    gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntci
    tnghcfaiieeddqgettlasgcmkyegsdfqckdspkaqlrrtieccrtnlcnqylqpt
    lppvvigpffdgsir
    

    Sequence, based on observed residues (ATOM records): (download)
    >3qb4D (D:)
    dtlpflkcycsghcpddainntcitnghcfaiieeddqgettlasgcmkyegsdfqckds
    pkaqlrrtieccrtnlcnqylqptlppvv