PDB entry 3q5l

View 3q5l on RCSB PDB site
Description: Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin
Class: chaperone
Keywords: SLEEPING SICKNESS, LEISHMANIA, HEAT SHOCK PROTEIN, Structural Genomics, Structural Genomics Consortium, SGC, CHAPERONE
Deposited on 2010-12-28, released 2011-02-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock protein 83-1
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF33.0312
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4Q4I6 (18-End)
      • expression tag (12-17)
    Domains in SCOPe 2.08: d3q5la1, d3q5la2
  • Chain 'B':
    Compound: Heat shock protein 83-1
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF33.0312
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4Q4I6 (18-End)
      • expression tag (12-17)
    Domains in SCOPe 2.08: d3q5lb1, d3q5lb2
  • Chain 'C':
    Compound: Heat shock protein 83-1
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF33.0312
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4Q4I6 (18-End)
      • expression tag (10-17)
    Domains in SCOPe 2.08: d3q5lc1, d3q5lc2
  • Chain 'D':
    Compound: Heat shock protein 83-1
    Species: Leishmania major [TaxId:5664]
    Gene: LMJF33.0312
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4Q4I6 (18-End)
      • expression tag (11-17)
    Domains in SCOPe 2.08: d3q5ld1, d3q5ld2
  • Heterogens: KX2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3q5lA (A:)
mhhhhhhssgrenlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacd
kiryqsltdpsvlgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtka
fmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe
sdmkrgtritlhlkedqmeyleprrlkelikkhsefigydielmvekttek

    Sequence, based on observed residues (ATOM records): (download) 
    >3q5lA (A:)
nlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacdkiryqsltdpsv
lgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtkafmealeaggdms
migqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitsmkrgtritlhlkedq
meyleprrlkelikkhsefigydielmve

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3q5lB (B:)
mhhhhhhssgrenlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacd
kiryqsltdpsvlgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtka
fmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe
sdmkrgtritlhlkedqmeyleprrlkelikkhsefigydielmvekttek

    Sequence, based on observed residues (ATOM records): (download) 
    >3q5lB (B:)
nlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacdkiryqsltdpsv
lgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtkafmealeaggdms
migqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpesdmkrgtritlh
lkedqmeyleprrlkelikkhsefigydielmve

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3q5lC (C:)
mhhhhhhssgrenlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacd
kiryqsltdpsvlgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtka
fmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe
sdmkrgtritlhlkedqmeyleprrlkelikkhsefigydielmvekttek

    Sequence, based on observed residues (ATOM records): (download) 
    >3q5lC (C:)
renlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacdkiryqsltdp
svlgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtkafmealeaggd
msmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpesdmkrgtrit
lhlkedqmeyleprrlkelikkhsefigydielmve

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3q5lD (D:)
mhhhhhhssgrenlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacd
kiryqsltdpsvlgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtka
fmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe
sdmkrgtritlhlkedqmeyleprrlkelikkhsefigydielmvekttek

    Sequence, based on observed residues (ATOM records): (download) 
    >3q5lD (D:)
enlyfqgmtetfafqaeinqlmsliintfysnkeiflrelisnasdacdkiryqsltdps
vlgesprlcirvvpdkenktltvedngigmtkadlvnnlgtiarsgtkafmealeaggdm
smigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpesdmkrgtritl
hlkedqmeyleprrlkelikkhsefigydielmve