PDB entry 3q0t

View 3q0t on RCSB PDB site
Description: Crystal structure of human dpp-iv in complex withsa-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5h-pyrrolo[3,4-b]pyridin-6(7h)-yl)acetate
Class: hydrolase/hydrolase inhibitor
Keywords: EXOPEPTIDASE, ALPHA/BETA HYDROLASE FOLD, BETA BARREL, BETA PROPELLER, AMINOPEPTIDASE, GLYCOPROTEIN, MEMBRANE, SERINE PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, hydrolase-hydrolase inhibitor complex
Deposited on 2010-12-16, released 2012-02-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3q0ta1, d3q0ta2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3q0tb1, d3q0tb2
  • Heterogens: NAG, LGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3q0tA (A:)
efsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfd
efghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvt
wspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalww
spngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsl
ssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgr
wnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctf
itkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqy
ysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldf
iilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiva
sfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvt
smvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfk
qveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythms
hfikqcfslppleqkliseedlnsavdhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3q0tA (A:)
rktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefg
hsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwsp
vghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssv
tnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnc
lvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitk
gtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysv
sfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiil
netkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmv
lgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfi
kqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3q0tB (B:)
efsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfd
efghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvt
wspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalww
spngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsl
ssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgr
wnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctf
itkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqy
ysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldf
iilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiva
sfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvt
smvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfk
qveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythms
hfikqcfslppleqkliseedlnsavdhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3q0tB (B:)
rktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefg
hsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwsp
vghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssv
tnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnc
lvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitk
gtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysv
sfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiil
netkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmv
lgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfi
kqcfslp