PDB entry 3pvu

View 3pvu on RCSB PDB site
Description: Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
Class: transferase/signaling protein/inhibitor
Keywords: Transferase, Serine/threonine-protein kinase, ATP-binding, Inhibitor, Membrane, TRANSFERASE-SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2010-12-07, released 2011-06-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: 0.229
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Bos taurus [TaxId:9913]
    Gene: ADRBK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3pvua1, d3pvua2, d3pvua3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3pvub_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3pvug_
  • Heterogens: QRW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3pvuA (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclkhleeakplvefyeeikkyekleteeerlvcsreifdtyimkellac
    shpfsksaiehvqghlvkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    ktknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprapvvelskvpliqrgsanglhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pvuA (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclkhleeakplvefyeei
    kkyekleteeerlvcsreifdtyimkellacshpfsksaiehvqghlvkkqvppdlfqpy
    ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
    kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
    ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
    hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
    pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
    spffrsldwqmvflqkyppplipprgdsdqelyrnfpltiserwqqevaetvfdtinaet
    drlearkktknkqlgheedyalgkdcimhgymskmgwqrryfylfpnrlewrgegeapqs
    lltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvq
    rvpkmknkp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3pvuB (B:)
    mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
    mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
    csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
    tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
    fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
    kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pvuB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >3pvuG (G:)
    hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
    pasenpfrekkffc
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pvuG (G:)
    siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
    c