PDB entry 3pp0
View 3pp0 on RCSB PDB site
Description: Crystal Structure of the Kinase domain of Human HER2 (erbB2).
Class: transferase/transferase inhibitor
Keywords: KINASE DOMAIN, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TYROSINE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2010-11-23, released
2011-03-30
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-06-15, with a file datestamp of
2011-06-10.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.189
AEROSPACI score: 0.38
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Receptor tyrosine-protein kinase erbB-2
Species: Homo sapiens [TaxId:9606]
Gene: ERBB2, HER2, MLN19, NEU, NGL
Database cross-references and differences (RAF-indexed):
- Uniprot P04626 (4-End)
- engineered mutation (4)
- engineered mutation (9-10)
Domains in SCOPe 2.02: d3pp0a_ - Chain 'B':
Compound: Receptor tyrosine-protein kinase erbB-2
Species: Homo sapiens [TaxId:9606]
Gene: ERBB2, HER2, MLN19, NEU, NGL
Database cross-references and differences (RAF-indexed):
- Uniprot P04626 (4-307)
- engineered mutation (4)
- engineered mutation (9-10)
Domains in SCOPe 2.02: d3pp0b_ - Heterogens: 03Q, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3pp0A (A:)
msgaapnqallrilketelrkvkvlgsgafgtvykgiwipdgenvkipvaikvlrentsp
kankeildeayvmagvgspyvsrllgicltstvqlvtqlmpygclldhvrenrgrlgsqd
llnwcmqiakgmsyledvrlvhrdlaarnvlvkspnhvkitdfglarlldideteyhadg
gkvpikwmalesilrrrfthqsdvwsygvtvwelmtfgakpydgipareipdllekgerl
pqppictidvymimvkcwmidsecrprfrelvsefsrmardpqrfvviqnedlgpaspld
stfyrslledddmgdlvdaeeylvpqqgaaashhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3pp0A (A:)
apnqallrilketelrkvkvlgsgafgtvykgiwipdgenvkipvaikvlrentspkank
eildeayvmagvgspyvsrllgicltstvqlvtqlmpygclldhvrenrgrlgsqdllnw
cmqiakgmsyledvrlvhrdlaarnvlvkspnhvkitdfglarlldideteyhagkvpik
wmalesilrrrfthqsdvwsygvtvwelmtfgakpydgipareipdllekgerlpqppic
tidvymimvkcwmidsecrprfrelvsefsrmardpqrfvviqned
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3pp0B (B:)
msgaapnqallrilketelrkvkvlgsgafgtvykgiwipdgenvkipvaikvlrentsp
kankeildeayvmagvgspyvsrllgicltstvqlvtqlmpygclldhvrenrgrlgsqd
llnwcmqiakgmsyledvrlvhrdlaarnvlvkspnhvkitdfglarlldideteyhadg
gkvpikwmalesilrrrfthqsdvwsygvtvwelmtfgakpydgipareipdllekgerl
pqppictidvymimvkcwmidsecrprfrelvsefsrmardpqrfvviqnedlgpaspld
stfyrslledddmgdlvdaeeylvpqqgaaashhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3pp0B (B:)
apnqallrilketelrkvkvlgsgafgtvykgiwipdgenvkipvaikvlrentspkank
eildeayvmagvgspyvsrllgicltstvqlvtqlmpygclldhvrenrgrlgsqdllnw
cmqiakgmsyledvrlvhrdlaarnvlvkspnhvkitdfglarlldideteyhagkvpik
wmalesilrrrfthqsdvwsygvtvwelmtfgakpydgipareipdllekgerlpqppic
tidvymimvkcwmidsecrprfrelvsefsrmardpqrfvviqnepldstfyrsll