PDB entry 3pjc

View 3pjc on RCSB PDB site
Description: Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family
Class: transferase/transferase inhibitor
Keywords: Small molecule inhibitor, ATP site kinase inhibitor, ATP-binding, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-11-09, released 2010-12-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-09-28, with a file datestamp of 2011-09-23.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.182
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3pjca_
  • Heterogens: PJC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3pjcA (A:)
gpqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfq
reiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrllly
ssqickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqs
pifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalcr
llelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsrgcetha
ftahpegkhhslsfs

    Sequence, based on observed residues (ATOM records): (download) 
    >3pjcA (A:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygslrlvmeylpsgclrdflqrhrarldasrlllyssqickgme
ylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapes
lsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalcrllelleegq
rlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsrg