PDB entry 3pj8

View 3pj8 on RCSB PDB site
Description: Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.
Class: transferase/transferase inhibitor
Keywords: PHOSPHORYLATION, CELL DIVISION, MITOSIS, Cyclin, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-11-09, released 2011-04-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-05-11, with a file datestamp of 2011-05-06.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: 0.206
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-298)
      • expression tag (0)
    Domains in SCOPe 2.07: d3pj8a1, d3pj8a2
  • Heterogens: 404, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3pj8A (A:)
    gmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
    hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
    shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
    ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
    fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pj8A (A:)
    gmenfqkvekigegtygvvykarnkltgevvalkkiretegvpstaireisllkelnhpn
    ivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshr
    vlhrdlkpqnllintegaikladfglarafgvvvtlwyrapeillgckyystavdiwslg
    cifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfsk
    vvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl