PDB entry 3pdc

View 3pdc on RCSB PDB site
Description: Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: epoxide hydrolase, hydrolase, hypertension, beta barrel, alpha/beta hydrolase fold; epoxide hydrolase fold, Acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. Has low phosphatase activity, Binds Mg2+, Acetylation of lysine, cytoplasm; peroxisome, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2010-10-22, released 2011-04-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-04-06, with a file datestamp of 2011-04-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.279
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epoxide hydrolase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHX2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3pdca_
  • Chain 'B':
    Compound: Epoxide hydrolase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHX2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3pdcb_
  • Heterogens: ZYI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3pdcA (A:)
    mgsshhhhhhssglvprgshmaplptscnpsdmshgyvtvkprvrlhfvelgsgpavclc
    hgfpeswyswryqipalaqagyrvlamdmkgygessappeieeycmevlckemvtfldkl
    glsqavfighdwggmlvwymalfypervravaslntpfipanpnmsplesikanpvfdyq
    lyfqepgvaeaeleqnlsrtfkslfrasdesvlsmhkvceagglfvnspeepslsrmvte
    eeiqfyvqqfkksgfrgplnwyrnmernwkwackslgrkilipalmvtaekdfvlvpqms
    qhmedwiphlkrghiedcghwtqmdkptevnqilikwldsdarn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pdcA (A:)
    aplptscnpsdmshgyvtvkprvrlhfvelgsgpavclchgfpeswyswryqipalaqag
    yrvlamdmkgygessappeieeycmevlckemvtfldklglsqavfighdwggmlvwyma
    lfypervravaslntpfipanpnmsplesikanpvfdyqlyfqepgvaeaeleqnlsrtf
    kslfrasdesvlsmhkvceagglfvnspeepslsrmvteeeiqfyvqqfkksgfrgplnw
    yrnmernwkwackslgrkilipalmvtaekdfvlvpqmsqhmedwiphlkrghiedcghw
    tqmdkptevnqilikwldsdarn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3pdcB (B:)
    mgsshhhhhhssglvprgshmaplptscnpsdmshgyvtvkprvrlhfvelgsgpavclc
    hgfpeswyswryqipalaqagyrvlamdmkgygessappeieeycmevlckemvtfldkl
    glsqavfighdwggmlvwymalfypervravaslntpfipanpnmsplesikanpvfdyq
    lyfqepgvaeaeleqnlsrtfkslfrasdesvlsmhkvceagglfvnspeepslsrmvte
    eeiqfyvqqfkksgfrgplnwyrnmernwkwackslgrkilipalmvtaekdfvlvpqms
    qhmedwiphlkrghiedcghwtqmdkptevnqilikwldsdarn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pdcB (B:)
    aplptscnpsdmshgyvtvkprvrlhfvelgsgpavclchgfpeswyswryqipalaqag
    yrvlamdmkgygessappeieeycmevlckemvtfldklglsqavfighdwggmlvwyma
    lfypervravaslntpfipanpnmsplesikanpvfdyqlyfqepgvaeaeleqnlsrtf
    kslfrasdesvlsmhkvceagglfvnspeepslsrmvteeeiqfyvqqfkksgfrgplnw
    yrnmernwkwackslgrkilipalmvtaekdfvlvpqmsqhmedwiphlkrghiedcghw
    tqmdkptevnqilikwldsdarn