PDB entry 3p9w

View 3p9w on RCSB PDB site
Description: Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
Class: signaling protein/immune system
Keywords: VH, Cystine Knot Cytokine, VEGF-R, SIGNALING PROTEIN, SIGNALING PROTEIN-IMMUNE SYSTEM complex
Deposited on 2010-10-18, released 2012-04-18
The last revision prior to the SCOPe 2.02 freeze date was dated 2013-04-03, with a file datestamp of 2013-03-29.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: 0.195
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Vascular Endothelial Growth Factor A
  Species: Homo sapiens [TaxId:9606]
  Gene: RP1-261G23.1-009, VEGF, VEGFA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P15692
• Chain 'B':
  Compound: human VEGF
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 3P9W (0-122)
  Domains in SCOPe 2.02: d3p9wb_
• Chain 'C':
  Compound: Vascular Endothelial Growth Factor A
  Species: Homo sapiens [TaxId:9606]
  Gene: RP1-261G23.1-009, VEGF, VEGFA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P15692
  Domains in SCOPe 2.02: d3p9wc_
• Chain 'D':
  Compound: human VEGF
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 3P9W
• Chain 'E':
  Compound: Vascular Endothelial Growth Factor A
  Species: Homo sapiens [TaxId:9606]
  Gene: RP1-261G23.1-009, VEGF, VEGFA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P15692
• Chain 'F':
  Compound: human VEGF
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 3P9W (Start-122)
• Chain 'G':
  Compound: Vascular Endothelial Growth Factor A
  Species: Homo sapiens [TaxId:9606]
  Gene: RP1-261G23.1-009, VEGF, VEGFA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P15692
• Chain 'H':
  Compound: human VEGF
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 3P9W (Start-122)
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3p9wB (B:)
  evqlvesggglvqpggslrlscaasgfnikdtyigwvrrapgkgeelvariyptngytry
  adsvkgrftisadtskntaylqmnslraedtavyycyyhyygwhpgyglsyssgqgtlvt
  vss
  

  
  
• Chain 'C':
  Sequence, based on SEQRES records: (download)
  

  >3p9wC (C:)
  gsqnhhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndegl
  ecvpteesnitmqimrikphqgqhigemsflqhnkcecrpkkdrar
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3p9wC (C:)
  hevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvpt
  eesnitmqimrikphqgqhigemsflqhnkcecrpkk
  

  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.