PDB entry 3oy3
View 3oy3 on RCSB PDB site
Description: Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589
Class: transferase/transferase inhibitor
Keywords: Protein-inhibitor complex, Protein kinase two-domain fold, phosphotransferase, ATP binding, phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2010-09-22, released
2010-12-15
The last revision prior to the SCOPe 2.06 freeze date was dated
2010-12-22, with a file datestamp of
2010-12-17.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.22
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase ABL1
Species: Mus musculus [TaxId:10090]
Gene: Abl1, Abl
Database cross-references and differences (RAF-indexed):
- Uniprot P00520 (1-283)
- expression tag (0)
- engineered mutation (87)
Domains in SCOPe 2.06: d3oy3a1, d3oy3a2 - Chain 'B':
Compound: Tyrosine-protein kinase ABL1
Species: Mus musculus [TaxId:10090]
Gene: Abl1, Abl
Database cross-references and differences (RAF-indexed):
- Uniprot P00520 (1-283)
- expression tag (0)
- engineered mutation (87)
Domains in SCOPe 2.06: d3oy3b1, d3oy3b2 - Heterogens: XY3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3oy3A (A:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelg
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3oy3B (B:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelg