PDB entry 3olf

View 3olf on RCSB PDB site
Description: Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid
Class: hormone receptor
Keywords: nuclear receptor, cholesterol, bile acid, DNA-binding, nucleus, receptor, transcription, ligand binding domain transcription regulation, coactivator, fxr alternative splicing, hormone receptor
Deposited on 2010-08-26, released 2011-01-19
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-02-26, with a file datestamp of 2014-02-21.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.206
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bile acid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1H4, hCG_20893
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RI1 (4-232)
      • expression tag (3)
      • engineered mutation (37)
      • engineered mutation (110)
    Domains in SCOPe 2.05: d3olfa_
  • Chain 'B':
    Compound: Peptide of Nuclear receptor coactivator 1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Bile acid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1H4, hCG_20893
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RI1 (4-232)
      • expression tag (3)
      • engineered mutation (37)
      • engineered mutation (110)
    Domains in SCOPe 2.05: d3olfc_
  • Chain 'D':
    Compound: Peptide of Nuclear receptor coactivator 1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: OLF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3olfA (A:)
gshmeltpdqqtllhfimdsynkqrmpqeitnkilkeafsaeenfliltematnhvqvlv
eftkklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdllearirnsgisd
eyitpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklc
kihqpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdvq

    Sequence, based on observed residues (ATOM records): (download) 
    >3olfA (A:)
meltpdqqtllhfimdsynkqrmpqeitnkilkeafsaeenfliltematnhvqvlveft
kklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdllearirnsgisdeyi
tpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckih
qpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdvq

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3olfC (C:)
gshmeltpdqqtllhfimdsynkqrmpqeitnkilkeafsaeenfliltematnhvqvlv
eftkklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdllearirnsgisd
eyitpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklc
kihqpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdvq

    Sequence, based on observed residues (ATOM records): (download) 
    >3olfC (C:)
meltpdqqtllhfimdsynkqrmpqeitnkilkeafsaeenfliltematnhvqvlveft
kklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdllearirnsgisdeyi
tpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckih
qpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdvq

  • Chain 'D':
    No sequence available.