PDB entry 3oj2
View 3oj2 on RCSB PDB site
Description: Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation
Class: Cytokine/Signaling Protein
Keywords: beta trefoil motif, Immunoglobulin-like domain, growth factor, growth factor receptor, extracellular, Cytokine-Signaling Protein complex
Deposited on
2010-08-20, released
2011-08-31
The last revision prior to the SCOPe 2.05 freeze date was dated
2012-03-07, with a file datestamp of
2012-03-02.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.262
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: heparin-binding growth factor 1
Species: Homo sapiens [TaxId:9606]
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3oj2a_ - Chain 'B':
Compound: heparin-binding growth factor 1
Species: Homo sapiens [TaxId:9606]
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3oj2b_ - Chain 'C':
Compound: Fibroblast growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: BEK, FGFR2, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
- Uniprot P21802 (Start-174)
- engineered mutation (33)
- see remark 999 (175-220)
Domains in SCOPe 2.05: d3oj2c1, d3oj2c2 - Chain 'D':
Compound: Fibroblast growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: BEK, FGFR2, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
- Uniprot P21802 (Start-174)
- engineered mutation (33)
- see remark 999 (175-220)
Domains in SCOPe 2.05: d3oj2d1, d3oj2d2 - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3oj2A (A:)
maegeittftaltekfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlq
lsaesvgevyikstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaek
nwfvglkkngsckrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>3oj2A (A:)
ppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyikstetgq
ylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngsckrgprt
hygqkailflplpvs
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3oj2B (B:)
maegeittftaltekfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlq
lsaesvgevyikstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaek
nwfvglkkngsckrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>3oj2B (B:)
ppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyikstetgq
ylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngsckrgprt
hygqkailflplpvs
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3oj2C (C:)
maedfvsensnnkrapywtntekmekrlhavpafntvkfrcpaggnpmptmrwlkngkef
kqehriggykvrnqhwslimesvvpsdkgnytcvveneygsinhtyhldvversphrpil
qaglpanastvvggdvefvckvysdaqphiqwikhvekngskygpdglpylkvlkhsgin
ssnaevlalfnvteadageyickvsnyigqanqsawltvlpkqqapgreke
Sequence, based on observed residues (ATOM records): (download)
>3oj2C (C:)
krapywtntekmekrlhavpafntvkfrcpaggnpmptmrwlkngkefkqehriggykvr
nqhwslimesvvpsdkgnytcvveneygsinhtyhldvversphrpilqaglpanastvv
ggdvefvckvysdaqphiqwikhvekngskygpdglpylkvlkhsginssnaevlalfnv
teadageyickvsnyigqanqsawltvlp
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3oj2D (D:)
maedfvsensnnkrapywtntekmekrlhavpafntvkfrcpaggnpmptmrwlkngkef
kqehriggykvrnqhwslimesvvpsdkgnytcvveneygsinhtyhldvversphrpil
qaglpanastvvggdvefvckvysdaqphiqwikhvekngskygpdglpylkvlkhsgin
ssnaevlalfnvteadageyickvsnyigqanqsawltvlpkqqapgreke
Sequence, based on observed residues (ATOM records): (download)
>3oj2D (D:)
krapywtntekmekrlhavpafntvkfrcpaggnpmptmrwlkngkefkqehriggykvr
nqhwslimesvvpsdkgnytcvveneygsinhtyhldvversphrpilqaglpanastvv
ggdvefvckvysdaqphiqwikhvekngskygpdglpylkvlkhsginssnaevlalfnv
teadageyickvsnyigqanqsawltvlp