PDB entry 3ofi
View 3ofi on RCSB PDB site
Description: Crystal structure of human insulin-degrading enzyme in complex with ubiquitin
Class: Hydrolase
Keywords: protein-peptide complex, hydrolase, human insulin-degrading enzyme, ubiquitin, exosite
Deposited on
2010-08-15, released
2010-09-08
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-02-23, with a file datestamp of
2011-02-18.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.21
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Insulin-degrading enzyme
Species: Homo sapiens [TaxId:9606]
Gene: IDE
Database cross-references and differences (RAF-indexed):
- Uniprot P14735
- engineered mutation (80-81)
- engineered mutation (141)
- engineered mutation (148)
- engineered mutation (227)
- engineered mutation (384)
- engineered mutation (543)
- engineered mutation (560)
- engineered mutation (759)
- engineered mutation (782)
- engineered mutation (789)
- engineered mutation (874)
- Chain 'B':
Compound: Insulin-degrading enzyme
Species: Homo sapiens [TaxId:9606]
Gene: IDE
Database cross-references and differences (RAF-indexed):
- Uniprot P14735
- engineered mutation (80-81)
- engineered mutation (141)
- engineered mutation (148)
- engineered mutation (227)
- engineered mutation (384)
- engineered mutation (543)
- engineered mutation (560)
- engineered mutation (759)
- engineered mutation (782)
- engineered mutation (789)
- engineered mutation (874)
- Chain 'C':
Compound: Ubiquitin
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d3ofic_ - Chain 'D':
Compound: Ubiquitin
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d3ofid_ - Heterogens: ZN, DIO, HOH