PDB entry 3oaw

View 3oaw on RCSB PDB site
Description: 4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors
Class: transferase/transferase inhibitor
Keywords: Phosphoinositide kinase, transferase-transferase, inhibition, inhibitor complex., TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-08-05, released 2010-09-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-10-06, with a file datestamp of 2010-10-01.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.21
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3oawa1, d3oawa2, d3oawa3, d3oawa4
  • Heterogens: OAW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3oawA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3oawA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmdfvlrvcgrde
ylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeslwdcdrkfrvkirgidi
pvlltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiyc
vqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsisilldnyc
hpialpraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvk
wgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvl
hyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavil
eaylrgcgtamlhdftqqvqviemlqkvtldikslsssqvisqlkqklenlqnsqlpesf
rvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdml
ilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafk
devlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhi
dfghilgnyrvpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfs
mmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl
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