PDB entry 3o57
View 3o57 on RCSB PDB site
Description: Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: PDE, HYDROLASE, PHOSPHODIESTERASE, cAMP Binding, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2010-07-28, released
2011-08-03
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-08-03, with a file datestamp of
2011-07-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Species: Homo sapiens [TaxId:9606]
Gene: PDE4B, DPDE4
Database cross-references and differences (RAF-indexed):
- Uniprot Q07343 (1-End)
- engineered mutation (331)
- engineered mutation (336)
Domains in SCOPe 2.06: d3o57a_ - Heterogens: ZN, MG, ARS, ZG2, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3o57A (A:)
msisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfr
issdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifa
aaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkq
rqtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhc
adlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyi
vhplwetwadlvqpdaqdildtlednrnwyqamipqapappldeqnrdcqglm
Sequence, based on observed residues (ATOM records): (download)
>3o57A (A:)
sisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfri
ssdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaa
aihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqr
qtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhca
dlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyiv
hplwetwadlvqpdaqdildtlednrnwyqamipqa