PDB entry 3nzu

View 3nzu on RCSB PDB site
Description: Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase
Class: transferase/transferase inhibitor
Keywords: kinase p110, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-07-16, released 2010-12-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-12-29, with a file datestamp of 2010-12-24.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.214
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3nzua1, d3nzua2, d3nzua3, d3nzua4
  • Heterogens: NZU

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3nzuA (A:)
sqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskp
lpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipesqs
eqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeewplv
ddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvfvean
iqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapalsskas
aespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkltsat
npdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatdplnp
ltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgl
tmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfllkrgl
rnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqviemlqkvt
ldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckvmas
kkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlcllp
ygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqaave
rfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginkervpfv
ltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqltske
dieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgihhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3nzuA (A:)
qafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskpl
peylwkkianncifivihrsttsqtikvspddtpgailqsfdfvlrvcgrdeylvgetpi
knfqwvrhclkngeeihvvldtppdpaldevrkcdrkfrvkirgidipvlprntdltvfv
eaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycllyyvnll
lidhrfllrrgeyvlhmwqisfnadkltsatnpdkensmsisilldempnqlrkqleaii
atdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdq
saldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalar
fllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvi
emlqkvtldikslydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckv
maskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlc
llpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqa
averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyrvpfvltpdfl
fvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqltskedieyir
daltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgi