PDB entry 3n2u
View 3n2u on RCSB PDB site
Description: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide
Class: Hydrolase/Hydrolase inhibitor
Keywords: MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE-INHIBITOR), METALLO ELASTASE, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-INDING, METALLOPROTEASE, PROTEASE, SECRETED, ZYMOGEN, Hydrolase-Hydrolase inhibitor complex
Deposited on
2010-05-19, released
2010-11-10
The last revision prior to the SCOPe 2.01 freeze date was dated
2010-12-08, with a file datestamp of
2010-12-03.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: 0.166
AEROSPACI score: 0.53
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3n2ua_ - Heterogens: ZN, CA, D3X, HOH