SCOPe 2.08: Structural Classification of Proteins

PDB entry 3my0

View 3my0 on RCSB PDB site
Description: Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189
Class: transferase
Keywords: Protein Kinase, Serine/threonine-protein kinase receptor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2010-05-08, released 2010-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-04-01, with a file datestamp of 2015-03-27.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0a1, d3my0a2
Chain 'B':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
Domains in SCOPe 2.08: d3my0b_
Chain 'C':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0c1, d3my0c2
Chain 'D':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0d1, d3my0d2
Chain 'E':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0e1, d3my0e2
Chain 'F':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0f1, d3my0f2
Chain 'G':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0g1, d3my0g2
Chain 'H':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0h1, d3my0h2
Chain 'I':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0i1, d3my0i2
Chain 'J':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023
Domains in SCOPe 2.08: d3my0j_
Chain 'K':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
Domains in SCOPe 2.08: d3my0k_
Chain 'L':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0l1, d3my0l2
Chain 'M':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0m1, d3my0m2
Chain 'N':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0n1, d3my0n2
Chain 'O':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0o1, d3my0o2
Chain 'P':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
Domains in SCOPe 2.08: d3my0p_
Chain 'Q':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0q1, d3my0q2
Chain 'R':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0r1, d3my0r2
Chain 'S':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0s1, d3my0s2
Chain 'T':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0t1, d3my0t2
Chain 'U':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0u1, d3my0u2
Chain 'V':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0v1, d3my0v2
Chain 'W':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
  - expression tag (1)
Domains in SCOPe 2.08: d3my0w1, d3my0w2
Chain 'X':
Compound: Serine/threonine-protein kinase receptor R3
Species: Homo sapiens [TaxId:9606]
Gene: ACVRL1, ACVRL1 (ALK1), ACVRLK1, ALK1
Database cross-references and differences (RAF-indexed):
- Uniprot P37023 (2-End)
Domains in SCOPe 2.08: d3my0x_
Heterogens: LDN, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3my0A (A:)
smqrtvarqvalvecvgkgrygevwrglwhgesvavkifssrdeqswfreteiyntvllr
hdnilgfiasdmtsrnsstqlwlithyhehgslydflqrqtlephlalrlavsaacglah
lhveifgtqgkpaiahrdfksrnvlvksnlqcciadlglavmhsqgsdyldignnprvgt
krymapevldeqirtdcfesykwtdiwafglvlweiarrtivngivedyrppfydvvpnd
psfedmkkvvcvdqqtptipnrlaadpvlsglaqmmrecwypnpsarltalrikktlqki
snspe