PDB entry 3mo5

View 3mo5 on RCSB PDB site
Description: Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72
Class: transferase
Keywords: Epigenetics, Histone lysine methylation, enzymatic inhibition, lysine mimics, TRANSFERASE
Deposited on 2010-04-22, released 2010-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-06-30, with a file datestamp of 2010-06-25.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: 0.196
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
    Species: Homo sapiens [TaxId:9606]
    Gene: EHMT1, EUHMTASE1, KIAA1876, KMT1D
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3mo5a_
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
    Species: Homo sapiens [TaxId:9606]
    Gene: EHMT1, EUHMTASE1, KIAA1876, KMT1D
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3mo5b_
  • Chain 'C':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
    Species: Homo sapiens [TaxId:9606]
    Gene: EHMT1, EUHMTASE1, KIAA1876, KMT1D
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3mo5c_
  • Chain 'D':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
    Species: Homo sapiens [TaxId:9606]
    Gene: EHMT1, EUHMTASE1, KIAA1876, KMT1D
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3mo5d_
  • Heterogens: ZN, E72, SAH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mo5A (A:)
nsqvwsalqmskalqdsapdrpspverivsrdiargyeripipcvnavdsepcpsnykyv
sqncvtspmnidrnithlqycvciddcsssncmcgqlsmrcwydkdgrllpefnmaeppl
ifecnhacscwrncrnrvvqnglrarlqlyrtrdmgwgvrslqdippgtfvceyvgelis
dseadvreedsylfdldnkdgevycidarfygnvsrfinhhcepnlvpvrvfmahqdlrf
priaffstrlieageqlgfdygerfwdikgklfscrcgspkcrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >3mo5A (A:)
ivsrdiargyeripipcvnavdsepcpsnykyvsqncvtspmnidrnithlqycvciddc
sssncmcgqlsmrcwydkdgrllpefnmaepplifecnhacscwrncrnrvvqnglrarl
qlyrtrdmgwgvrslqdippgtfvceyvgelisdseadvreedsylfdldgevycidarf
ygnvsrfinhhcepnlvpvrvfmahqdlrfpriaffstrlieageqlgfdygerfwdikg
klfscrcgspkcrhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mo5B (B:)
nsqvwsalqmskalqdsapdrpspverivsrdiargyeripipcvnavdsepcpsnykyv
sqncvtspmnidrnithlqycvciddcsssncmcgqlsmrcwydkdgrllpefnmaeppl
ifecnhacscwrncrnrvvqnglrarlqlyrtrdmgwgvrslqdippgtfvceyvgelis
dseadvreedsylfdldnkdgevycidarfygnvsrfinhhcepnlvpvrvfmahqdlrf
priaffstrlieageqlgfdygerfwdikgklfscrcgspkcrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >3mo5B (B:)
erivsrdiargyeripipcvnavdsepcpsnykyvsqncvtspmnidrnithlqycvcid
dcsssncmcgqlsmrcwydkdgrllpefnmaepplifecnhacscwrncrnrvvqnglra
rlqlyrtrdmgwgvrslqdippgtfvceyvgelisdseadvreedsylfdldnkevycid
arfygnvsrfinhhcepnlvpvrvfmahqdlrfpriaffstrlieageqlgfdygerfwd
ikgklfscrcgspkcrhs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3mo5C (C:)
nsqvwsalqmskalqdsapdrpspverivsrdiargyeripipcvnavdsepcpsnykyv
sqncvtspmnidrnithlqycvciddcsssncmcgqlsmrcwydkdgrllpefnmaeppl
ifecnhacscwrncrnrvvqnglrarlqlyrtrdmgwgvrslqdippgtfvceyvgelis
dseadvreedsylfdldnkdgevycidarfygnvsrfinhhcepnlvpvrvfmahqdlrf
priaffstrlieageqlgfdygerfwdikgklfscrcgspkcrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >3mo5C (C:)
verivsrdiargyeripipcvnavdsepcpsnykyvsqncvtspmnidrnithlqycvci
ddcsssncmcgqlsmrcwydkdgrllpefnmaepplifecnhacscwrncrnrvvqnglr
arlqlyrtrdmgwgvrslqdippgtfvceyvgelisdseadvreedsylfdldgevycid
arfygnvsrfinhhcepnlvpvrvfmahqdlrfpriaffstrlieageqlgfdygerfwd
ikgklfscrcgspkcrhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3mo5D (D:)
nsqvwsalqmskalqdsapdrpspverivsrdiargyeripipcvnavdsepcpsnykyv
sqncvtspmnidrnithlqycvciddcsssncmcgqlsmrcwydkdgrllpefnmaeppl
ifecnhacscwrncrnrvvqnglrarlqlyrtrdmgwgvrslqdippgtfvceyvgelis
dseadvreedsylfdldnkdgevycidarfygnvsrfinhhcepnlvpvrvfmahqdlrf
priaffstrlieageqlgfdygerfwdikgklfscrcgspkcrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >3mo5D (D:)
erivsrdiargyeripipcvnavdsepcpsnykyvsqncvtspmnidrnithlqycvcid
dcsssncmcgqlsmrcwydkdgrllpefnmaepplifecnhacscwrncrnrvvqnglra
rlqlyrtrdmgwgvrslqdippgtfvceyvgelisdseadvreedsylfdldevycidar
fygnvsrfinhhcepnlvpvrvfmahqdlrfpriaffstrlieageqlgfdygerfwdik
gklfscrcgspkcrhs