PDB entry 3mkp

View 3mkp on RCSB PDB site
Description: Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin
Class: hormone
Keywords: growth factor, supramolecular assembly, HGF/SF, Met receptor, NK1, HORMONE
Deposited on 2010-04-15, released 2010-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hepatocyte growth factor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210
      • engineered mutation (104)
      • engineered mutation (106)
    Domains in SCOPe 2.08: d3mkpa1, d3mkpa2
  • Chain 'B':
    Compound: hepatocyte growth factor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210
      • engineered mutation (104)
      • engineered mutation (106)
    Domains in SCOPe 2.08: d3mkpb1, d3mkpb2
  • Chain 'C':
    Compound: hepatocyte growth factor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210
      • engineered mutation (104)
      • engineered mutation (106)
    Domains in SCOPe 2.08: d3mkpc1, d3mkpc2
  • Chain 'D':
    Compound: hepatocyte growth factor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210
      • engineered mutation (104)
      • engineered mutation (106)
    Domains in SCOPe 2.08: d3mkpd1, d3mkpd2
  • Heterogens: SO4, EPE, SGN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mkpA (A:)
yaegqrkrrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckaf
vfdkarkqclwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgi
kcqpwssmiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcs
eve

    Sequence, based on observed residues (ATOM records): (download) 
    >3mkpA (A:)
rntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckafvfdkarkq
clwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgikcqpwssm
iphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcse

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mkpB (B:)
yaegqrkrrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckaf
vfdkarkqclwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgi
kcqpwssmiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcs
eve

    Sequence, based on observed residues (ATOM records): (download) 
    >3mkpB (B:)
rntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckafvfdkarkq
clwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgikcqpwssm
iphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcse

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3mkpC (C:)
yaegqrkrrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckaf
vfdkarkqclwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgi
kcqpwssmiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcs
eve

    Sequence, based on observed residues (ATOM records): (download) 
    >3mkpC (C:)
rntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckafvfdkarkq
clwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgikcqpwssm
iphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcse

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3mkpD (D:)
yaegqrkrrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckaf
vfdkarkqclwfpfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgi
kcqpwssmiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcs
eve

    Sequence, based on observed residues (ATOM records): (download) 
    >3mkpD (D:)
hefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckafvfdkarkqclwf
pfnsmssgvkkefghefdlyenkdyirnciigegesykgtvsitksgikcqpwssmiphe
hsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcse