PDB entry 3m3z

View 3m3z on RCSB PDB site
Description: Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor
Class: protein binding
Keywords: grp78, hsp70, hsc70, chaperone, heat shock, protein folding, ATP-binding, adenosine, nucleoside, nucleotide-binding, stress response, endoplasmatic reticulum, small molecule inhibitor, selectivity, host-virus interaction, phosphoprotein, alternative initiation, apoptosis, nucleus, protein binding
Deposited on 2010-03-10, released 2011-01-26
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-06-29, with a file datestamp of 2011-06-24.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.205
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock cognate 71 kDa protein
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA8, HSC70, HSP73, HSPA10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3m3za1, d3m3za2
  • Chain 'B':
    Compound: BAG family molecular chaperone regulator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BAG1, HAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99933 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.05: d3m3zb_
  • Heterogens: 3F5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3m3zA (A:)
yfqgpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqva
mnptntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevs
smvltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlriineptaaa
iaygldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnh
fiaefkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitra
rfeelnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkeln
ksinpdeavaygaavqaails

    Sequence, based on observed residues (ATOM records): (download) 
    >3m3zA (A:)
pavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqvamnpt
ntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevssmvl
tkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlriineptaaaiayg
ldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnhfiae
fkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitrarfee
lnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkelnksin
pdeavaygaavqaails

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3m3zB (B:)
gnspqeevelkklkhleksvekiadqleelnkeltgiqqgflpkdlqaealckldrrvka
tieqfmkileeidtlilpenfkdsrlkrkglvkkvqaflaecdtveqnicqete

    Sequence, based on observed residues (ATOM records): (download) 
    >3m3zB (B:)
gnspqeevelkklkhleksvekiadqleelnkeltgiqqgflpkdlqaealckldrrvka
tieqfmkileeidtlilpenfkdsrlkrkglvkkvqaflaecdtveqnicq