PDB entry 3m36

View 3m36 on RCSB PDB site
Description: Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)
Class: hydrolase
Keywords: GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, Blood coagulation, Cleavage on pair of basic residues, Disulfide bond, EGF-like domain, Gamma-carboxyglutamic acid, Polymorphism, Protease, Secreted, Zymogen
Deposited on 2010-03-08, released 2010-04-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-04-21, with a file datestamp of 2010-04-16.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.226
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: coagulation factor x
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00742 (0-233)
  Domains in SCOPe 2.08: d3m36a_
• Chain 'L':
  Compound: coagulation factor x
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00742 (0-51)
  Domains in SCOPe 2.08: d3m36l_
• Heterogens: M35, CA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3m36A (A:)
  ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
  qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
  tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
  cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
  

  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3m36L (L:)
  klcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle