PDB entry 3m1b

View 3m1b on RCSB PDB site
Description: Crystal structure of human FcRn with a dimeric peptide inhibitor
Class: immune system/inhibitor
Keywords: IMMUNOGLOBULIN BINDING PROTEIN, Cell membrane, Disulfide bond, Glycoprotein, IgG-binding protein, Immunoglobulin domain, Membrane, Receptor, Transmembrane, Amyloid, Amyloidosis, Disease mutation, Glycation, Immune response, MHC I, Pyrrolidone carboxylic acid, Secreted, IMMUNE SYSTEM-IMMUNE SYSTEM INHIBITOR, IMMUNE SYSTEM-INHIBITOR complex
Deposited on 2010-03-04, released 2010-06-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-08-24, with a file datestamp of 2011-08-19.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.318
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1ba1, d3m1ba2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1bb_
  • Chain 'C':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1bc1, d3m1bc2
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1bd_
  • Chain 'E':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1be1, d3m1be2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1bf_
  • Chain 'G':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1bg1, d3m1bg2
  • Chain 'H':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3m1bh_
  • Chain 'I':
    Compound: dimeric peptide inhibitor
    Database cross-references and differences (RAF-indexed):
    • PDB 3M1B
  • Chain 'J':
    Compound: dimeric peptide inhibitor
    Database cross-references and differences (RAF-indexed):
    • PDB 3M1B (1-End)

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3m1bA (A:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvel
    

    Sequence, based on observed residues (ATOM records): (download)
    >3m1bA (A:)
    lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
    ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
    gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
    karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
    gdehhyccivqhaglaqplrvel
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3m1bB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3m1bC (C:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvel
    

    Sequence, based on observed residues (ATOM records): (download)
    >3m1bC (C:)
    lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
    ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
    gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
    karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
    gdehhyccivqhaglaqplrvel
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3m1bD (D:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >3m1bE (E:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvel
    

    Sequence, based on observed residues (ATOM records): (download)
    >3m1bE (E:)
    lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
    ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
    gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
    karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
    gdehhyccivqhaglaqplrvel
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3m1bF (F:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >3m1bG (G:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvel
    

    Sequence, based on observed residues (ATOM records): (download)
    >3m1bG (G:)
    lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
    ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
    gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
    karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
    gdehhyccivqhaglaqplrvel
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3m1bH (H:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.