PDB entry 3m1b
View 3m1b on RCSB PDB site
Description: Crystal structure of human FcRn with a dimeric peptide inhibitor
Class: immune system/inhibitor
Keywords: IMMUNOGLOBULIN BINDING PROTEIN, Cell membrane, Disulfide bond, Glycoprotein, IgG-binding protein, Immunoglobulin domain, Membrane, Receptor, Transmembrane, Amyloid, Amyloidosis, Disease mutation, Glycation, Immune response, MHC I, Pyrrolidone carboxylic acid, Secreted, IMMUNE SYSTEM-IMMUNE SYSTEM INHIBITOR, IMMUNE SYSTEM-INHIBITOR complex
Deposited on
2010-03-04, released
2010-06-16
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-08-24, with a file datestamp of
2011-08-19.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.318
AEROSPACI score: 0.07
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: igg receptor fcrn large subunit p51
Species: Homo sapiens [TaxId:9606]
Gene: FCGRT, FCRN
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1ba1, d3m1ba2 - Chain 'B':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1bb_ - Chain 'C':
Compound: igg receptor fcrn large subunit p51
Species: Homo sapiens [TaxId:9606]
Gene: FCGRT, FCRN
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1bc1, d3m1bc2 - Chain 'D':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1bd_ - Chain 'E':
Compound: igg receptor fcrn large subunit p51
Species: Homo sapiens [TaxId:9606]
Gene: FCGRT, FCRN
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1be1, d3m1be2 - Chain 'F':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1bf_ - Chain 'G':
Compound: igg receptor fcrn large subunit p51
Species: Homo sapiens [TaxId:9606]
Gene: FCGRT, FCRN
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1bg1, d3m1bg2 - Chain 'H':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Gene: B2M, CDABP0092, HDCMA22P
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3m1bh_ - Chain 'I':
Compound: dimeric peptide inhibitor
Database cross-references and differences (RAF-indexed):
- Chain 'J':
Compound: dimeric peptide inhibitor
Database cross-references and differences (RAF-indexed):
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3m1bA (A:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvel
Sequence, based on observed residues (ATOM records): (download)
>3m1bA (A:)
lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
gdehhyccivqhaglaqplrvel
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3m1bB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3m1bC (C:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvel
Sequence, based on observed residues (ATOM records): (download)
>3m1bC (C:)
lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
gdehhyccivqhaglaqplrvel
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>3m1bD (D:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'E':
Sequence, based on SEQRES records: (download)
>3m1bE (E:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvel
Sequence, based on observed residues (ATOM records): (download)
>3m1bE (E:)
lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
gdehhyccivqhaglaqplrvel
- Chain 'F':
Sequence; same for both SEQRES and ATOM records: (download)
>3m1bF (F:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'G':
Sequence, based on SEQRES records: (download)
>3m1bG (G:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvel
Sequence, based on observed residues (ATOM records): (download)
>3m1bG (G:)
lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
gdehhyccivqhaglaqplrvel
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>3m1bH (H:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'I':
No sequence available.
- Chain 'J':
No sequence available.