PDB entry 3lxc

View 3lxc on RCSB PDB site
Description: Interconversion of Human Lysosomal Enzyme Specificities
Class: hydrolase
Keywords: GLYCOPROTEIN, CARBOHYDRATE-BINDING PROTEIN, GLYCOSIDASE, LYSOSOMAL ENZYME, (BETA/ALPHA)8 BARREL, ENZYME INTERCONVERSION, Disease mutation, Disulfide bond, Hydrolase, Lysosome
Deposited on 2010-02-25, released 2010-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-galactosidase A
    Species: Homo sapiens [TaxId:9606]
    Gene: GLA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06280 (0-End)
      • engineered (171)
      • engineered (174)
    Domains in SCOPe 2.08: d3lxca1, d3lxca2
  • Chain 'B':
    Compound: Alpha-galactosidase A
    Species: Homo sapiens [TaxId:9606]
    Gene: GLA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06280 (0-End)
      • engineered (171)
      • engineered (174)
    Domains in SCOPe 2.08: d3lxcb1, d3lxcb2
  • Heterogens: NAG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lxcA (A:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentmqmslkdllhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3lxcA (A:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentmq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lxcB (B:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentmqmslkdllhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3lxcB (B:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentm