PDB entry 3lx9

View 3lx9 on RCSB PDB site
Description: Interconversion of Human Lysosomal Enzyme Specificities
Class: hydrolase
Keywords: GLYCOPROTEIN, CARBOHYDRATE-BINDING PROTEIN, GLYCOSIDASE, LYSOSOMAL ENZYME, (BETA/ALPHA)8 BARREL, ENZYME INTERCONVERSION, Disease mutation, Disulfide bond, Hydrolase, Lysosome
Deposited on 2010-02-25, released 2010-05-05
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-06-01, with a file datestamp of 2011-05-27.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: 0.178
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-galactosidase A
    Species: Homo sapiens [TaxId:9606]
    Gene: GLA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06280 (0-End)
      • engineered (171)
      • engineered (174)
    Domains in SCOPe 2.05: d3lx9a1, d3lx9a2
  • Chain 'B':
    Compound: Alpha-galactosidase A
    Species: Homo sapiens [TaxId:9606]
    Gene: GLA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06280 (0-End)
      • engineered (171)
      • engineered (174)
    Domains in SCOPe 2.05: d3lx9b1, d3lx9b2
  • Heterogens: NAG, A2G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lx9A (A:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentmqmslkdllhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3lx9A (A:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentmq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lx9B (B:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentmqmslkdllhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3lx9B (B:)
ldnglartptmgwlhwerfmcnldcqeepdsciseklfmemaelmvsegwkdagyeylci
ddcwmapqrdsegrlqadpqrfphgirqlanyvhskglklgiyadvgnktcagfpgsfgy
ydidaqtfadwgvdllkfdgcycdslenladgykhmslalnrtgrsivyscswpaymwpf
qkpnyteirqycnhwrnfadiddswksiksildwtsfnqerivdvagpggwndpdmlvig
nfglswnqqvtqmalwaimaaplfmsndlrhispqakallqdkdviainqdplgkqgyql
rqgdnfevwerplsglawavaminrqeiggprsytiavaslgkgvacnpacfitqllpvk
rklgfyewtsrlrshinptgtvllqlentm