PDB entry 3len

View 3len on RCSB PDB site
Description: Human Aldose Reductase mutant T113S complexed with Zopolrestat
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Tim Barrel, T113S mutant, Oxidoreductase, NADP, Phosphoprotein, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2010-01-15, released 2011-01-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-08-24, with a file datestamp of 2011-08-19.
Experiment type: XRAY
Resolution: 1.21 Å
R-factor: 0.124
AEROSPACI score: 0.86 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: ALR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (Start-315)
      • see remark 999 (4)
      • engineered mutation (113)
    Domains in SCOPe 2.08: d3lena_
  • Heterogens: NAP, ZST, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3lenA (A:)
    masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
    eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwpsgfkpgk
    effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
    avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
    hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
    llsctshkdypfheef
    

    Sequence, based on observed residues (ATOM records): (download)
    >3lenA (A:)
    srillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqek
    lreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwpsgfkpgkef
    fpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpav
    nqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakhn
    kttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcall
    sctshkdypfheef