PDB entry 3le6

View 3le6 on RCSB PDB site
Description: The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor
Class: transferase/transferase inhibitor
Keywords: Cyclin-Dependent Kinase 2 Drug Design, ATP-binding, Cell cycle, Cell division, Kinase, Mitosis, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase-Transferase inhibitor complex
Deposited on 2010-01-14, released 2010-11-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-11-17, with a file datestamp of 2010-11-12.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.196
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3le6a_
  • Heterogens: 2BZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3le6A (A:)
    menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
    pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
    hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
    stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
    pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3le6A (A:)
    menfqkvekigegtygvvykarnkltgevvalkkipstaireisllkelnhpnivklldv
    ihtklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlkpq
    nllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiwslgc
    ifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskv
    vppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp