PDB entry 3l4q

View 3l4q on RCSB PDB site
Description: Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
Class: viral protein/protein binding
Keywords: PI3K, PHOSPHOINOSITIDE-3-KINASE, INFLUENZA VIRUS, NS1, Kinase, VIRAL PROTEIN-PROTEIN BINDING complex
Deposited on 2009-12-21, released 2010-02-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.235
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-structural protein 1
    Species: Influenza A virus [TaxId:211044]
    Gene: NS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3l4qa_
  • Chain 'B':
    Compound: Non-structural protein 1
    Species: Influenza A virus [TaxId:211044]
    Gene: NS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3l4qb_
  • Chain 'C':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit beta
    Species: Bos taurus [TaxId:9913]
    Gene: PIK3R2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23726 (Start-169)
      • engineered (73)
    Domains in SCOPe 2.08: d3l4qc_
  • Chain 'D':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit beta
    Species: Bos taurus [TaxId:9913]
    Gene: PIK3R2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23726 (Start-169)
      • engineered (73)
    Domains in SCOPe 2.08: d3l4qd_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3l4qA (A:)
hhhhhhsdealkmtmasvpasryltdmtleemsrdwsmlipkqkvagplcirmdqaimdk
niilkanfsvifdrletlillrafteegaivgeisplpslpghtaedvknavgvliggle
wndntvrvsetlqrfawrssnengrppltpkqkremagtirsev

    Sequence, based on observed residues (ATOM records): (download) 
    >3l4qA (A:)
svpasryltdmtleemsrdwsmlipkqkvagplcirmdqaimdkniilkanfsvifdrle
tlillrafteegaivgeisplpslpghtaedvknavgvligglewndntvrvsetlqrfa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3l4qB (B:)
hhhhhhsdealkmtmasvpasryltdmtleemsrdwsmlipkqkvagplcirmdqaimdk
niilkanfsvifdrletlillrafteegaivgeisplpslpghtaedvknavgvliggle
wndntvrvsetlqrfawrssnengrppltpkqkremagtirsev

    Sequence, based on observed residues (ATOM records): (download) 
    >3l4qB (B:)
vpasryltdmtleemsrdwsmlipkqkvagplcirmdqaimdkniilkanfsvifdrlet
lillrafteegaivgeisplpslpghtaedvknavgvligglewndntvrvsetlqrfa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3l4qC (C:)
yqqdqivkedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnet
ikifeeqgqtqeksskeylerfrregnekemqrillnserlksriaeihesrtkleqelr
aqasdnreidkrmnslkpdlmqlrkirdqylvwltqkgarqkkinewlgi

    Sequence, based on observed residues (ATOM records): (download) 
    >3l4qC (C:)
kedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnetikifeeq
gqtqeksskeylerfrregnekemqrillnserlksriaeihesrtkleqelraqasdnr
eidkrmnslkpdlmqlrkirdqylvwltqkgarqkkinewlgi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3l4qD (D:)
yqqdqivkedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnet
ikifeeqgqtqeksskeylerfrregnekemqrillnserlksriaeihesrtkleqelr
aqasdnreidkrmnslkpdlmqlrkirdqylvwltqkgarqkkinewlgi

    Sequence, based on observed residues (ATOM records): (download) 
    >3l4qD (D:)
kedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnetikifeeq
gqtqeksskeylerfrregnekemqrillnserlksriaeihesrtkleqelraqasdnr
eidkrmnslkpdlmqlrkirdqylvwltqkgarqkkinewlgi