PDB entry 3krx

View 3krx on RCSB PDB site
Description: Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)
Class: protein binding
Keywords: RGS HOMOLOGY DOMAIN, ATP-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Transducer, WD repeat, Cell membrane, Lipoprotein, Membrane, Methylation, Prenylation, PROTEIN BINDING
Deposited on 2009-11-19, released 2010-02-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-01-05, with a file datestamp of 2010-12-31.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.232
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3krxa1, d3krxa2, d3krxa3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3krxb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3krxg_
  • Heterogens: BA1, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3krxA (A:)
    adleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifsq
    klgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellacs
    hpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknve
    lnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalneri
    mlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaaei
    ilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymapev
    lqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspel
    rsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaad
    afdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrlearkk
    aknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsll
    tmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqrv
    pkmknkprspvvelskvplvqrgsangl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3krxA (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
    kkyekleteeervarsreifdsyimkellahpfsksatehvqghlgkkqvppdlfqpyie
    eicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrka
    dtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfil
    dlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehghv
    risdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghspf
    rqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkesp
    ffrsldwqmvflqkyppplippreedtkgiklldsdqelyrnfpltiserwqqevaetvf
    dtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmwqrryfylfpnrlewrge
    geapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayre
    aqqlvqrvpkmknkprsp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3krxB (B:)
    mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
    mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
    csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
    tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
    fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
    kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3krxB (B:)
    eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
    wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
    iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
    htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
    tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
    dragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >3krxG (G:)
    hhhhhhmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpv
    pasenpfrekkffc
    

    Sequence, based on observed residues (ATOM records): (download)
    >3krxG (G:)
    siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
    c