PDB entry 3kps

View 3kps on RCSB PDB site
Description: Crystal Structure of the LC13 TCR in complex with HLA B*4405 bound to EEYLQAFTY a self peptide from the ABCD3 protein
Class: immune system
Keywords: HLA B*4405, TCRpMHC structure, ternary complex, allorecognition, TCR recognition, self peptide, Disulfide bond, Glycoprotein, Host-virus interaction, Immune response, Membrane, MHC I, Polymorphism, IMMUNE SYSTEM
Deposited on 2009-11-16, released 2009-12-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-04-21, with a file datestamp of 2010-04-16.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.197
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, B-44 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-B, HLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30481 (0-275)
      • variant (115)
    Domains in SCOPe 2.06: d3kpsa1, d3kpsa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3kpsb_
  • Chain 'C':
    Compound: EEYLQAFTY, self peptide from the ATP binding cassette protein ABCD3
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPS (0-8)
  • Chain 'D':
    Compound: LC13 TCR alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPS (0-200)
    Domains in SCOPe 2.06: d3kpsd1, d3kpsd2
  • Chain 'E':
    Compound: LC13 TCR beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3KPS (0-240)
    Domains in SCOPe 2.06: d3kpse1, d3kpse2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3kpsA (A:)
    gshsmryfytamsrpgrgeprfitvgyvddtlfvrfdsdatsprkeprapwieqegpeyw
    dretqisktntqtyrenlrtalryynqseagshiiqrmygcdvgpdgrllrgydqyaydg
    kdyialnedlsswtaadtaaqitqrkweaarvaeqdrayleglcveslrrylengketlq
    radppkthvthhpisdhevtlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdrt
    fqkwaavvvpsgeeqrytchvqheglpkpltlrwep
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3kpsB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3kpsD (D:)
    kttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrmasl
    aiaedrksstlilhratlrdaavyycilplaggtsygkltfgqgtiltvhpniqnpdpav
    yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdktvldmrsmdfksnsavawsnks
    dfacanafnnsiipedtffps
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3kpsE (E:)
    gvsqsprykvakrgqdvalrcdpisghvslfwyqqalgqgpefltyfqneaqldksglps
    drffaerpegsvstlkiqrtqqedsavylcasslgqayeqyfgpgtrltvtedlknvfpp
    evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeqpal
    ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
    d