PDB entry 3kf4

View 3kf4 on RCSB PDB site
Description: Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template
Class: transferase
Keywords: Abl, CML, drug resistance, inhibitor, ATP-binding, Kinase, Nucleotide-binding, Oncogene, Tyrosine-protein kinase, TRANSFERASE
Deposited on 2009-10-27, released 2009-12-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-09-01, with a file datestamp of 2010-08-27.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.197
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL1
    Species: Mus musculus [TaxId:10090]
    Gene: Abl, Abl1, c-Abl
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3kf4a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase ABL1
    Species: Mus musculus [TaxId:10090]
    Gene: Abl, Abl1, c-Abl
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3kf4b_
  • Heterogens: B90, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3kf4A (A:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkrgt

    Sequence, based on observed residues (ATOM records): (download) 
    >3kf4A (A:)
spnydkwemertditmkhklgggqygevyegvwkkysltvavktlkveeflkeaavmkei
khpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqissamey
lekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslay
nkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmr
acwqwnpsdrpsfaeihqafetmfqessisdevekelgkrg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3kf4B (B:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkrgt

    Sequence, based on observed residues (ATOM records): (download) 
    >3kf4B (B:)
spnydkwemertditmkhklgggqygevyegvwkkysltvavktltmeveeflkeaavmk
eikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqissam
eylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesl
aynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyel
mracwqwnpsdrpsfaeihqafetmfqess