PDB entry 3kcg
View 3kcg on RCSB PDB site
Description: Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
Class: hydrolase, hydrolase inhibitor
Keywords: Michaelis complex, Blood coagulation, Calcium, Disulfide bond, EGF-like domain, Glycoprotein, Hemophilia, Hydrolase, Pharmaceutical, Protease, Secreted, Serine protease, Sulfation, Zymogen, Heparin-binding, Protease inhibitor, Serine protease inhibitor, Thrombophilia
Deposited on
2009-10-21, released
2010-02-02
The last revision prior to the SCOPe 2.04 freeze date was dated
2010-02-02, with a file datestamp of
2010-01-29.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.208
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Coagulation factor IXa heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d3kcgh_ - Chain 'I':
Compound: antithrombin-III
Species: Homo sapiens [TaxId:9606]
Gene: SERPINC1, AT3, PRO0309
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d3kcgi_ - Chain 'L':
Compound: Coagulation factor IXa light chain
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
- Uniprot P00740 (1-End)
- initiating methionine (0)
Domains in SCOPe 2.04: d3kcgl_ - Heterogens: CA, NTP, MPD, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>3kcgH (H:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgrsalvlqylrvplvdratclrstkftiynnmfcagfheggrds
cqgdaggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt
- Chain 'I':
Sequence, based on SEQRES records: (download)
>3kcgI (I:)
hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
fffaklncrlyrkankasklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
ifmgrvanpcvk
Sequence, based on observed residues (ATOM records): (download)
>3kcgI (I:)
spvdictakprdipmnpmciyrspeqkipeatnrrvwelskansrfattfyqhladsknd
ndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyr
kankasklvsanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsn
ktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmm
yqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldele
emmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaf
levneegseaaastavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcv
- Chain 'L':
Sequence, based on SEQRES records: (download)
>3kcgL (L:)
mdvtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtsk
Sequence, based on observed residues (ATOM records): (download)
>3kcgL (L:)
mdvtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsv