SCOPe 2.03: Structural Classification of Proteins

PDB entry 3kc3

View 3kc3 on RCSB PDB site
Description: MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine
Class: transferase
Keywords: MAPKAP-K2, MK2, TNFalpha, diaminopyrimidine, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2009-10-20, released 2010-01-12
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.233
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3a_
Chain 'B':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3b_
Chain 'C':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137 (0-End)
Domains in SCOPe 2.03: d3kc3c_
Chain 'D':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3d_
Chain 'E':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3e_
Chain 'F':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3f_
Chain 'G':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3g_
Chain 'H':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3h_
Chain 'I':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3i_
Chain 'J':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3j_
Chain 'K':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3k_
Chain 'L':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: MAPKAPK2
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.03: d3kc3l_
Heterogens: MK2, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3kc3A (A:)
qqfpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpk
arrevelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafte
reaseimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnsl
ttpcytpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrir
mgqyefpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsr
vlkedkerwedvkeemtsalatmr