PDB entry 3k75

View 3k75 on RCSB PDB site
Description: X-ray crystal structure of reduced XRCC1 bound to DNA pol beta catalytic domain
Class: DNA-binding protein
Keywords: allosteric disulfide, XRCC1, pol beta, DNA damage, DNA repair, Nucleus, Phosphoprotein, DNA replication, DNA synthesis, DNA-binding, DNA-directed DNA polymerase, Lyase, Magnesium, Metal-binding, Methylation, Nucleotidyltransferase, Transferase, DNA-BINDING PROTEIN
Deposited on 2009-10-12, released 2010-04-28
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-09-05, with a file datestamp of 2012-08-31.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.245
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: DNA repair protein XRCC1
    Species: Homo sapiens [TaxId:9606]
    Gene: XRCC1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA repair protein XRCC1
    Species: Homo sapiens [TaxId:9606]
    Gene: XRCC1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA polymerase beta
    Species: Rattus norvegicus [TaxId:10116]
    Gene: POLB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06766 (1-245)
      • expression tag (246-248)
    Domains in SCOPe 2.03: d3k75d1, d3k75d2
  • Chain 'E':
    Compound: DNA polymerase beta
    Species: Rattus norvegicus [TaxId:10116]
    Gene: POLB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3k75e1, d3k75e2

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3k75D (D:)
mddtsssinfltrvtgigpsaarklvdegiktledlrknedklnhhqriglkyfedfekr
ipreemlqmqdivlnevkkldpeyiatvcgsfrrgaessgdmdvllthpnftsesskqpk
llhrvveqlqkvrfitdtlskgetkfmgvcqlpsendeneyphrridirlipkdqyycgv
lyftgsdifnknmrahalekgftineytirplgvtgvageplpvdseqdifdyiqwryre
pkdrsehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3k75D (D:)
ddtsssinfltrvtgigpsaarklvdegiktledlrknedklnhhqriglkyfedfekri
preemlqmqdivlnevkkldpeyiatvcgsfrrgaessgdmdvllthpnftsesskqpkl
lhrvveqlqkvrfitdtlskgetkfmgvcqlpsendeneyphrridirlipkdqyycgvl
yftgsdifnknmrahalekgftineytirplgvtgvageplpvdseqdifdyiqwryrep
kdrsehhh

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3k75E (E:)
mddtsssinfltrvtgigpsaarklvdegiktledlrknedklnhhqriglkyfedfekr
ipreemlqmqdivlnevkkldpeyiatvcgsfrrgaessgdmdvllthpnftsesskqpk
llhrvveqlqkvrfitdtlskgetkfmgvcqlpsendeneyphrridirlipkdqyycgv
lyftgsdifnknmrahalekgftineytirplgvtgvageplpvdseqdifdyiqwryre
pkdrsehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3k75E (E:)
tsssinfltrvtgigpsaarklvdegiktledlrknedklnhhqriglkyfedfekripr
eemlqmqdivlnevkkldpeyiatvcgsfrrgaessgdmdvllthpnftsesskqpkllh
rvveqlqkvrfitdtlskgetkfmgvcqlpsendeneyphrridirlipkdqyycgvlyf
tgsdifnknmrahalekgftineytirplgvtgvageplpvdseqdifdyiqwryrepkd
rse