PDB entry 3k74
View 3k74 on RCSB PDB site
Description: Disruption of protein dynamics by an allosteric effector antibody
Class: oxidoreductase
Keywords: Immunoglobulin, protein-nanobody complex, Antibiotic resistance, Methotrexate resistance, NADP, One-carbon metabolism, Oxidoreductase, Trimethoprim resistance
Deposited on
2009-10-12, released
2010-10-20
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-09-18, with a file datestamp of
2013-09-13.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.198
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Escherichia coli K-12 [TaxId:83333]
Gene: b0048, DHFR, folA, JW0047, tmrA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3k74a_ - Chain 'B':
Compound: Nanobody
Species: Lama glama [TaxId:9844]
Gene: Lama
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3k74b_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3k74A (A:)
misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsycfeilerr
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3k74B (B:)
qlqesggglvqpggslrlscaasgftfnnywmywvrrapgkglewvsminpggiitkyae
svkgrftisrdnakntlylqmnsltsedtavyycakdwatglakkgqgtqvtvss